de Bakker DEM,Mihaljević M, Gharat K, Richter Y, van Bebber F, Adam L, Shamim-Schulze F, Ohlenschläger O, Bens M, Cirri E, Antebi A, Matić I, Schneider A, Schmid B, Kirstein J, Valenzano DR. (2024). Amyloid Beta Precursor Protein contributes to brain aging and learning decline in short-lived turquoise killifish (Nothobranchius furzeri). bioRxiv 2024.10.11.617841; doi: https://doi.org/10.1101/2024.10.11.617841.
Cattelan S., Valenzano DR. (2024). Age-dependent decline in sperm quality and function in a naturally short-lived vertebrate bioRxiv 2023.12.13.571459; doi: https://doi.org/10.1101/2023.12.13.571459.
Morabito G, Ryabova A & Valenzano DR. (2024) Immune aging in annual killifish. Immun Ageing 21, 18 (2024). https://doi.org/10.1186/s12979-024-00418-3.
Morabito G, Davila Aleman FD, Valenzano DR. (2023). Assessing Age-Related Decline in Anti-Bacterial Immune Responses Using an Ex-vivo Assay in African Turquoise Killifish (Nothobranchius furzeri). bioRxiv 2023.11.24.568569; doi: https://doi.org/10.1101/2023.11.24.568569.
Xu A, Teefy BB, Lu RJ, Nozownik S, Tyers AM, Valenzano DR, Benayoun BA. (2023). Transcriptomes of aging brain, heart, muscle, and spleen from female and male African turquoise killifish. Scientific Data, 10, 695(2023); doi: https://doi.org/10.1038/s41597-023-02609-x.
Monzo C, Gkioni L, Beyer A, Valenzano DR^, Gronke S^, Partridge L^. (2023). Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity. Cell Reports, 42(7), 112722. https://doi.org/10.1016/j.celrep.2023.112722.
^corresponding authors
de Bakker DEM and Valenzano DR. (2023, in press). Turquoise killifish: a natural model of age-dependent brain degeneration. Ageing Research Reviews. https://doi.org/10.1016/j.arr.2023.102019.
Cattelan S, Valenzano DR. (2023). Noninvasive Ejaculate Collection from the African Turquoise Killifish (Nothobranchius furzeri). Cold Spring Harbor Protocols; Published in Advance February 13, 2023, doi: 10.1101/pdb.prot108155.
Morabito G, Donertas HM, Sperti L, Seidel J, Poursadegh A, Poeschla M, Valenzano DR. (2023). Spontaneous onset of cellular markers of inflammation and genome instability during aging in the immune niche of the naturally short-lived turquoise killifish (Nothobranchius furzeri). bioRxiv 2023.02.06.527346; doi: https://doi.org/10.1101/2023.02.06.527346.
Seidel J, Popkes M, Valenzano DR. (2023). Taxonomic Profiling of Fecal and Intestinal Microbiota in the African Turquoise Killifish Nothobranchius furzeri. Cold Spring Harb Protoc. 2023 Oct 3;2023(10):755-62. doi: 10.1101/pdb.prot107749.
Seidel J, Bradshaw WJ, Valenzano DR. (2023). Sequencing the Immunoglobulin Heavy-Chain Locus (IgH) in Turquoise Killifish (Nothobranchius furzeri). Cold Spring Harbor Protocols; doi: https://10.1101/pdb.prot107750.
Bagic M and Valenzano DR. (2022). Population size shapes the evolution of lifespan. bioRxiv 2022.12.17.520867; doi: https://doi.org/10.1101/2022.12.17.520867
Promislow D, Anderson RM, Scheffer M, Crespi B, DeGregori J, Harris K, Natterson Horowitz B, Levine ME, Riolo MA, Schneider DS, Spencer SL, Valenzano DR, Hochberg ME. (2022). Resilience Integrates Concepts in Aging Research. iScience, https://doi.org/10.1016/j.isci.2022.104199.
Bradshaw WJ, Poeschla M, Placzek A, Kean S, Valenzano DR. (2022). Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish. eLife 2022;11:e65117 https://elifesciences.org/articles/65117.
Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald CY, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Borch Jensen M, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegué E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. (2022). Meeting Report: Aging Research and Drug Discovery. Aging. 2022 Jan;14(2):530-543. https://10.18632/aging.203859. PMID: 35089871.
Khallaf MA, Cui R, Weissflog J, Svatoš A, Dweck HKM, Valenzano DR, Hansson BS, Knaden M. (2021). Large-scale characterization of sex pheromone communication systems in Drosophila. Nat Commun 12, 4165; https://doi.org/10.1038/s41467-021-24395-z.
Cui R, Tyers AM, Malubhoy ZJ, Wisotsky S, Valdesalici S, Henriette E, Kosakovsky Pond SL, Valenzano DR. (2021). Ancestral transoceanic colonization and recent population reduction in a non-annual killifish from the Seychelles archipelago. Molecular Ecology 30 (14); https://doi.org/10.1111/mec.15982.
Willemsen D, Cui R, Reichard M, Valenzano DR. (2020). Intra-species differences in population size shape life history and genome evolution. eLife 2020;9:e55794; https://doi.org/10.7554/eLife.55794.
Mkrtchyan GV, Abdelmohsen J,Andreux P,Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fei Fang E, Faragher R, Ferrucci L, Freund A, Silva-Garcia CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Borch Jensen M, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. (2020). ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY) 12 (24), 24484.
Popkes M, Valenzano DR. (2020). Microbiota-host interactions shape ageing dynamics. Phil. Trans. R. Soc. B 375: 20190596; http://doi.org/10.1098/rstb.2019.0596.
Cui R, Willemsen D, Valenzano DR. (2020). Nothobranchius furzeri (African Turquoise Killifish). Trends In Genetics; https://doi.org/10.1016/j.tig.2020.01.012.
Bradshaw WJ, Valenzano DR. (2020). Extreme genomic volatility characterises the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes. Proceedings of the Royal Society B, 287(1927) https://doi.org/10.1098/rspb.2020.0489.
Poeschla M, Valenzano DR. (2020). The turquoise killifish: a genetically tractable model for the study of aging. Journal of Experimental Biology, 223:jeb.209296, doi: 10.1242/jeb.209296.
Dolfi L, Ripa R, Antebi A, Valenzano DR, Cellerino A. (2019). Cell cycle dynamics during diapause entry and exit in an annual killifish revealed by FUCCI technology. EvoDevo, 10(1), 1-22, https://doi.org/10.1186/s13227-019-0142-5.
Aleman F.D.D., and Valenzano DR. (2019). Microbiome evolution during host aging. PLoS Pathogens 15, e1007727.
Metge F, Kim Y, Boucas J, Dieterich C, Valenzano DR. (2019). Circular RNAs in the ageing African turquoise killifish. bioRxiv, https://doi.org/10.1101/699694.
Cui R, Medeiros T, Willemsen D, Iasi LNM, Collier GE, Graef M, Reichard M, Valenzano DR. (2019). Relaxed Selection Limits Lifespan by Increasing Mutation Load. Cell, Jul 11;178:1-15 (cover article).
Bradshaw WJ, Šajina A, Valenzano DR. (2019). AEGIS: An In Silico Tool to model Genome Evolution in Age-Structured Populations. bioRxiv, https://doi.org/10.1101/646877.
Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Emilse Vargas N, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR^, Kurian L^. (2019). Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart . Embo Reports (2019) e47407. https://doi.org/10.15252/embr.201847407. ^Co-last authors.
Keesey IW, Grabe V, Gruber L, Koerte S, Obiero GF, Bolton G, Khallaf MA, Kunert G, Lavista-Llanos S, Valenzano DR, Rybak J, Barrett BA, Knaden M, Hansson BS. (2019). Inverse resource allocation between vision and olfaction across the genus Drosophila. Nature Communications. (2019)10:1162. https://doi.org/10.1038/s41467-019-09087-z.
Valenzano DR. (2018). Host-microbiota interactions during ageing. Old Herborn University Seminar Monograph 32: Ageing and the Microbiome. Old Herborn University Foundation, Herborn, Germany: 33-41.
Seidel J, Valenzano DR. (2018). The role of the gut microbiome during host ageing. F1000Research 2018, 7(F1000 Faculty Rev):1086. doi: 10.12688/f1000research.15121.1.
Muck J, Kean S, Valenzano DR. (2018). The short-lived African turquoise killifish (Nothobranchius furzeri): a new model system for research on ageing. In “Conn’s Handbook of Models of Human Aging, 2nd Ed (May 2018). ISBN: 978-0-12-811353-0.
Dodzian J, Kean S, Seidel J, Valenzano DR. (2018). A Protocol for Laboratory Housing of Turquoise Killifish (Nothobranchius furzeri). J. Vis. Exp. (134), e57073, doi:10.3791/57073.
Smith P, Willemsen D, Popkes M, Metge F, Gandiwa E, Reichard M, Valenzano DR. (2017). Regulation of Life Span by the Gut Microbiota in The Short-Lived African Turquoise Killifish. Elife. Aug 22;6. doi: 10.775/eLife.27014.
Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V. (2017). Non-canonical aging model systems and why we need them. EMBO J. DOI: 10.15252/embj.201796837.
Harel I, Valenzano DR, Brunet A. (2016). Efficient genome engineering in the short-lived African turquoise killifish. Nature Protocols. Oct; 11(10):2010-2028.
Kim Y, Nam HG, Valenzano DR. (2016). The short-lived African Turquoise Killifish: an Emerging Model for Ageing. DMM, Feb 3;9(2):115-129 (cover article).
Šajina A, Valenzano DR. (2016). An In Silico Model to Simulate the Evolution of Biological Aging. [bioRxiv] [arXiv]
Valenzano DR^#, Benayoun BA^, Singh PP^, Zhang E, Etter PD, Hu CK, Clement-Ziza M, Willemsen D, Cui R, Harel I, Machado B, Yee MC, Sharp SC, Bustamante CD, Beyer A, Johnson EA, Brunet A#. (2015). The African turquoise killifish genome provides insights into evolution and genetic architecture of lifespan. Cell, Dec 3;162(6):1539-1554. ^ Co-first; # co-corresponding.
Reichard M, Cellerino A, Valenzano DR. (2015). Turquoise Killifish. Current Biology. Aug;25(17): R741-2.
Cellerino A, Valenzano DR, Reichard M. (2015). From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology. Biological Reviews. DOI: 10.1111/brv.12183.
Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Valenzano DR, Zhang E, Sharp SC, Artandi SE, Brunet A. (2015). A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell. Feb 26;160(5):1013-26.
Publications before 2013 (selected)
Valenzano DR, Sharp S, Brunet A. (2011). Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri, a Vertebrate Model for Aging. G3 (Bethesda). Dec;1(7):531-8.
Valenzano DR^, Kirschner J^, Kamber RA, Zhang E, Weber D, Cellerino A, Englert C, Platzer M, Reichwald K, Brunet A. (2009). Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri. Genetics. Dec;183(4):1385-95. ^ Co-first.
Terzibasi E, Valenzano DR, Benedetti M, Roncaglia P, Cattaneo A, Domenici L, Cellerino A. (2008). Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri. PLoS One. 3(12):e3866.
Terzibasi E, Valenzano DR, Cellerino A. (2007). The short-lived fish Nothobranchius furzeri as a new model system for aging studies. Exp Gerontol. Jan-Feb;42(1-2):81-9.
Valenzano DR, Terzibasi E, Cattaneo A, Domenici L, Cellerino A. (2006). Temperature affects longevity and age-related locomotor and cognitive decay in the short-lived fish Nothobranchius furzeri. Aging Cell. Jun;5(3):275-8.
Valenzano DR, Cellerino A. (2006). Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule. Cell Cycle. May;5(10):1027-32.
Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A. (2006). Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. Feb 7;16(3):296-300.
Genade T, Benedetti M, Terzibasi E, Roncaglia P, Valenzano DR, Cattaneo A, Cellerino A. (2005). Annual fishes of the genus Nothobranchius as a model system for aging research. Aging Cell. Oct;4(5):223-33.